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Top1. Introduction
The skin is the largest organ of the human body. For an adult, the skin surface measures approximately 16,000 cm and represents about 8% of the body weight. Skin is normally affected by sunscreen, UV rays, heat rash, itching, lesions, dark spots, and other infections. Skin diseases are a general disease like other serious diseases (Roy, 2019; Trabelsi, 2013). According to the WHO, more than 2 million people are affected by non-melanoma and around 132,000 people are affected by melanoma (a type of cancer) through the skin each year worldwide. Therefore, all skin diseases are not cancerous (melanomas) (Chowdhury, 2016; George, 2016), but, some skin diseases are also developing as side effects of other chronic diseases. The skin has mainly two layers. The outer layer is known as the epidermis consisting of three cells, such as squamous, basal, and melanocytes, and the inner layer is known as the dermis. Usually, skin cancer starts from the epidermis (Cheng, 2012; Dos, 2008; Hasija, 2017; Manoorkar, 2016; Oselame, 2015; Patil, 2015; Zaidan, 2010).