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Top1. Introduction
Drug-Interaction and Drug side Effects are two important factors that need to consider before taking any drug. One drug may cause adverse effect to some drug consumers but provide better results to other. So other factors like age, gender, and other biological problem to patient must also be addressed while suggesting drugs. In order to provide effective drug prediction system, one must consider all the above-mentioned factors while providing the name of drugs because wrong suggestion may lead to disastrous result and even lead to death of any patient. If a patient is taking more than one drug predicting drug-drug interaction initially is very difficult and sometimes cause severe side effect. With more than one prescribed medicine chances of possible drug interaction is quite high. Old age patients and patients suffering from critical disease like cancer (Jurulink et al., 2003) (Van et al., 2010) have high chances of drug interaction and possibility of side effect due to intake of drug. So, precaution must be taken while suggesting drug to critical patient. Most of the drug-drug interaction and side effect are discovered accidentally when two or more drugs are prescribed by any healthcare professional to any patient, so clinical trial lead to the discovery of most drug-drug interaction (Percha, 2013). Many methods have been used in the past for discovering drug-drug interaction like finding out the drug interaction from scientific data (Kuhn et al.,2010) (He et al.,2013), dataset of insurance claim (Noren et al., 2008), electronic health records (Duke et al., 2012), and Adverse Event Reporting system (Tatonetti & N.P, 2012) but all the above mentioned methods rely on clinical experience and trial in the marketing of drug. All above methods are not effective in finding out drug-drug interaction and cannot alert any patient about the side effect (Tatonetti et al., 2012). So there is a need of mechanism which can suggest drug with very low error rate. It has been found that machine learning is very effective in healthcare domain especially in disease detection and drug suggestion (Rathi & Gupta, 2014). Medication or drug intake requires lot of knowledge of drug, its side effects, and its interaction with other medicines. We cannot afford to take a risk which is directly connected with people’s life as any mistake in diagnosis or treatment of a disease may lead to death of a patient. Globally, it is estimated that 142,000 people died in 2013 from adverse effects of medical treatment; this is an increase from 94,000 in 1990. However, a 2016 study of the number of deaths that were a result of medical error in the U.S. placed the yearly death rate in the U.S. alone at 251,454 deaths (GBD Mortality and Causes of Death, Collaborators, 2013).