Gene Selection from Microarray Data for Alzheimer's Disease Using Random Forest

Dataset

We obtained datasets of DNA microarray from the Gene Expression Omnibus (http://www.ncbi.nlm.nih.gov/geo/) (Edgar et al., 2002). The Gene Expression Omnibus contains numerous datasets of DNA microarray obtained from different species and environments of experiments. Since we had to select datasets obtained from homo sapiens, we conducted a search for such datasets using the following steps:

• 1.

  We searched the phrase “Alzheimer’s disease” and checked the box of “DataSets” to set Entry type, and limited the sample organism as “homo sapiens” on the Gene Expression Omnibus;

• 2.

  As a result, we obtained 13 papers discussing Alzheimer’s disease, and we downloaded datasets of DNA microarray referenced in these papers;

• 3.

  We selected datasets including samples from human brain cells.