Looking Into the Binary Interactome of Enterobacteriaceae Family of Bacteria

Background

At present, protein–protein interaction studies focus on the combinatorial complexity of functional interactome with an intention to build a viable cell from them. The bewildering combinatorial complexity of possible interactomes raises many questions on development as well as rewiring of PPIs along evolution. Peter Tompa and George Rose sketched a minimalistic combinatorial model (possible protein-protein interaction patterns) for yeast and concluded that a prior framework of existing interactions is essential, as emergent interactome cannot self-organise spontaneously (Tompa & Rose, 2011). In evolutionary terms, this implies that a particular PPI pattern (an interactome) is highly conserved physical entity and small variations are important phenotypic markers of species separation (Tompa & Rose, 2011; Kyaw, Pawan, Maria & Alessandro. 2006; Goh, Bogan, Joachimiak, Walther & Cohen, 2000). The analysis of eventual variation in the PPI patterns from the orchestrated protein interactions is thus of crucial importance in taxonomy.