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Top1. Introduction
Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) is a positive-sense single stranded RNA virus, casually known as the corona virus (Jin, Y et al., 2020). The virus was first identified in Wuhan, China by the Centres for Disease Control and Prevention (CDC) at December 2019 (Jin, Y et al., 2020). Since then, the virus has spread to other countries by infected people, and now this is a pandemic threat to global health (Xu, X et al., 2019). The virus spreads from person to person through close contact with someone who has the infection (Dietz, L et al., 2020). Usually, corona virus was spread via airborne zoonotic droplets. Different researches confirmed that corona viruses are replicated in ciliated epithelium that caused cellular damage and infection at infection site (Dietz, L et al., 2020). This disease is most infectious when a person is symptomatic (Dietz, L et al., 2020). However, it is possible for someone without symptoms to spread the virus (Xu, X et al., 2019). A new study suggests that 10% of infections are from people exhibiting no symptoms (Dietz, L et al., 2020). The diagnosed people experience fever, cough, potential loss of taste or smell and trouble breathing (Calmes, D et al., 2021, Mohan et al., N 2021). However, many people with COVID-19 recover with proper care and treatment (Calmes, D et al., 2021, Mohan, N et al. 2021). It may be noted that SARS-CoV-2 is newly recognized virus and many of researches are still ongoing, so it may possible that corona virus can spread in many other ways that are still unknown. According to the report of WHO, the two groups of people most at risk of experiencing severe illness due to a SARS-CoV-2 infection are older adults (defined as over 60 years old) and persons with other health issues (such as lung infections, diabetes, heart disease etc.) that compromise their immune system (Calmes, D et al., 2021, Mohan, N et al. 2021). Initially, the first confirmed cases reported on 1 January 2020 were related to the Huanan seafood market China, known as the birth place of this virus (Covid-19) (Calmes, D et al., 2021, Mohan, N 2021). Corona virus disease 2019 soon drew global attention because of the rapidly increasing numbers of new cases (Calmes, D et al., 2021, Mohan, N et al. 2021). The new type of corona virus infection was believed to have been transmitted from animals, and by January 2020 it was suspected that the initially affected patients had been infected with the virus through human-to-human transmission (WHO COVID-19 update 2021). Since January 2020, the spread of covid-19 has increased and the virus has extended rapidly to most parts of China as well as to other countries. As of 5th June 2021, a confirmed number of 183, 560, 151 people have been infected with SARS-CoV-2 globally; vaccine doses cases are reported as 2, 988, 941, 529 people and confirmed death are 3 978 581 people globally (WHO COVID-19 update 2021). These figures are updated daily and are expected to increase further. To control the spreading of infection, we should follow the preventive measurements such as to avoid close contact with patients having acute respiratory infections, repeatedly hand wash while in contact with infected person, avoid contact with wild or farm animals, maintain a distance approximately 1-1.5m person, people suffering from immune compromise avoid public gathering or use N95 mask while travelling. The aim of the recent review article was to have a preliminary opinion about the disease, the ways of diagnosis, treatment, and prevention in this early stage of this outbreak. Figure 1 shows the Cases reported globally till June 2021.