The fact that I started research in computational chemistry, particularly in QSAR modeling, after long experience at the University of Milano in a completely different field of chemistry, organic chemistry, carrying out experimental works on the synthesis and structural identification of natural products, certainly had relevant influence on how I dealt with the new research field in QSAR. Another fundamental element in my researches was to learn QSAR modeling from a leader in chemometrics and theoretical molecular descriptors, Prof. Roberto Todeschini of the University of Milano-Bicocca.