Systemic Approaches in Bioinformatics and Computational Systems Biology: Recent Advances
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Systemic Approaches in Bioinformatics and Computational Systems Biology: Recent Advances

Release Date: December, 2011|Copyright: © 2012 |Pages: 471
DOI: 10.4018/978-1-61350-435-2
ISBN13: 9781613504352|ISBN10: 1613504357|EISBN13: 9781613504369
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Description & Coverage
Description:

The convergence of biology and computer science was initially motivated by the need to organize and process a growing number of biological observations resulting from rapid advances in experimental techniques. Today, however, close collaboration between biologists, biochemists, medical researchers, and computer scientists has also generated remarkable benefits for the field of computer science.

Systemic Approaches in Bioinformatics and Computational Systems Biology: Recent Advances presents new techniques that have resulted from the application of computer science methods to the organization and interpretation of biological data. The book covers three subject areas: bioinformatics, computational biology, and computational systems biology. It focuses on recent, systemic approaches in computer science and mathematics that have been used to model, simulate, and more generally, experiment with biological phenomena at any scale.

Coverage:

The many academic areas covered in this publication include, but are not limited to:

  • Bioinformatics and Clinical Practice Analysis
  • Biological Network Inference
  • Biosystem Modeling
  • Cognition in Computers
  • Computational Sequence Design
  • DNA Microarray Technologies
  • High Performance Algorithms in Bioinformatics
  • Metabolomics
  • Molecular Cancer Classification
  • Role of Stochastic Simulation in Ecology
Reviews & Statements

The thorough expertise of the editors of the book, Paola Lecca, Dan Tulpan, and Kanagasabai Rajaraman, clearly shows in the thoughtful selection of contributions in this book. [...] The three of them carefully choose an outstanding excerpt of topics and of contributions which make this book a unique reference on the most challenging areas at the convergence of biology and computational sciences.

– Paola Quaglia, University of Trento, Italy

Driven by such opportunities and challenges, bioinformatics has rapidly expanded in scope and complexity over the last two decades. This book offers the readers a timely, broad, and useful introduction to these exciting developments.

– Limsoon Wong, National University of Singapore

Recommended- This specific volume is comprehensive in quality and quantity study concerning systemic approaches in the areas of Bioinformatics and Computational Systems Biology. [...] It covers a broad range of topics in a well structured way, while the material both theoretical and practical is being presented in an appropriate academic way, and contains novel content useful to both theoreticians and to the developers of practical applications.

– Christos Makris, University of Patras, Greece
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Editor/Author Biographies
Paola Lecca received a Master Degree in Theoretical Physics from the University of Trento (Italy) and a PhD in Computer Science from the International Doctorate School in Information and Communication Technologies at the University of Trento (Italy). Currently Paola Lecca is the Principal Investigator of the Inference and Data manipulation research group at The Microsoft Research – University of Trento Centre for Computational and Systems Biology (Trento,, Italy). Dr. Paola Lecca’s research interests include stochastic biochemical kinetic, biological networks inference, optimal experimental design in biochemistry, and computational cell biology. She designed prototypes for biological model calibration and for the simulation of diffusion pathways in cells and tissues. She has published articles in leading medical, biological and bioinformatics Journals and Conferences. She received a best paper prize at Brain, Vision and Artificial Intelligence (Naples, Italy 2007) presenting a kinetic model of cerebral glucose metabolism in astrocytes. Paola Lecca is carrying on an intense editorial activity, editing books and as editorial member of CSC bioinformatics journals. She is a member of the Italian Society of Pure and Applied Biophysics. Paola Lecca has experience in organizing international conferences and as PC member of many international conferences as well (SAC ACM, ISB, ICCB, ICCMB). More information, such as the complete list of publications and prototypes, the editorial activity, and the research interests of Paola Lecca are available at: http://www.cosbi.eu/index.php/people/people-research/16-paola-lecca.
Dan Tulpan received a BSc/B.eng. Degree (2000) from POLITEHNICA University of Bucharest (Romania) and a PhD Degree in Computer Science (2006) from the University of British Columbia (Canada). Dan is a research officer in the Knowledge Discovery Group at the Institute for Information Technology, National Research Council Canada and lead of the NRC-IIT Bioinformatics Laboratory. Dan is also appointed as Adjunct Professor (2010) in the Department of Biology, University of Moncton, Honorary Research Associate (2009) in the Department of Computer Science, University of New Brunswick and Research Associate (2009) at the Atlantic Cancer Research Institute in Moncton. Dan’s research interests include the development of algorithms and technologies in biotechnology (microarray probe design), bioinformatics (comparative genomics, metabolomics) and data analysis and visualization.
Rajaraman Kanagasabai is currently a Principal Investigator at the Data Mining Department, Institute for Infocomm Research (I2R), Singapore, and leads the Semantic Technology Group. He has widely published in top peer-reviewed journals and conferences, and served in the Programme Committees of many international conferences. He has also chaired or co-chaired several international events related to Bioinformatics, Bio Ontologies and Analytics. He was part of the core research team behind the multiple-award winning iAgent – the first multilingual search engine, WebWatch - the key technology behind the successful startup BuzzCity (www.buzzcity.com), and the KnowleSuite technology that has been spunoff as Knorex (www.knorex.com). He was also the leader of the team that won the Tan Kah Kee Young Inventor's Award for Web Data Extraction technology in 2006. His research interests include Semantic technologies, Bio Ontologies, SOA & Web services, text/web mining. He is on the web at: http://datam.i2r.a-star.edu.sg/~kanagasa/.
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