Applications of Gold Nanoparticles in Cancer

Applications of Gold Nanoparticles in Cancer

Solaimuthu Balakrishnan (Madras University, India), Firdous Ahmad Bhat (University of Madras, India) and Arunakaran Jagadeesan (University of Madras, India)
DOI: 10.4018/978-1-5225-0610-2.ch008
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Abstract

This chapter deals with the applications of gold nanoparticle in cancer and various strategies to target cancer cells by using gold nanoparticles. They are in great demand for biomedical applications such as DNA/Protein detection, bimolecular regulators, cell imaging and cancer cell diagnostics. The ability to tune the surface of the particle provides access to cell –specific targeting and controlled drug release. Depending on their size, shape, degree of aggregation, and local environment, gold nanoparticles can appear red, blue, or other colors. The novel drug delivery systems offer the opportunity to improve poor solubility, limited stability, bio distribution, and pharmacokinetics of drug as well as offering the potential ability to target specific tissues and cell types. The multifunctional gold nanoparticles are attractive organic –inorganic hybrid material composed of an inorganic metallic gold core surrounded by an organic or bimolecular monolayer they provide desirable attributes for the creation of drug delivery in cancer.
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Gold Nanoparticles

Gold Nanoparticles (AuNPs) are known for their unique optical and electronic properties. They produce vibrant colors upon interaction with visible light and thus were used by artisans in the past centuries. Gold nanoparticles have proved to be versatile for a range of applications with well characterized physical and electronic properties. Moreover, their surface chemistry can be easily modified. Their large surface area to volume ratio enables surface coating with a variety of molecules including therapeutics and target agents. Over the past few decades, inorganic nanoparticles, whose structures exhibit significantly novel and distinct physical, chemical, and biological properties, and functionality due to their nanoscale size, have elicited much interest.

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