Breast Cancer Stem Cells Targeted Strategies

Abstract

This chapter explores the complexity and heterogeneity of breast cancer stem cells (BCSCs), highlighting their flexibility and the epigenetic mechanisms that govern them. It examines molecular profiling techniques, the role of non-coding RNAs in maintaining stemness, and advanced therapies like CRISPR-Cas9, CAR-T cells, and nanomedicine. The chapter also addresses the tumour microenvironment's influence, synergistic treatments, and challenges in biomarker validation and clinical translation. Ethical issues related to genetic modification, informed consent, and patient autonomy in stem cell therapy are also discussed, providing a comprehensive overview of BCSC research.