Computational Analysis and Characterization of Marfan Syndrome Associated Human Proteins

Computational Analysis and Characterization of Marfan Syndrome Associated Human Proteins

K. Sivakumar
Copyright: © 2010 |Pages: 15
DOI: 10.4018/978-1-60566-768-3.ch009
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Abstract

Novel computational procedures and methods have been used to analyze, characterize and to provide more detailed definition of some Marfan syndrome associated human Fibrillin 1 proteins retrieved from NCBI Entrez protein database. Primary structure analysis reveals that the Marfan syndrome associated proteins are rich in cysteine and glycine residues. Extinction Coefficients of Marfan syndrome associated proteins at 280nm is ranging from 1490 to 259165 M-1 cm-1. Expasy’s ProtParam classifies most of the Marfan syndrome associated human Fibrillin 1 proteins as unstable on the basis of Instability index (II>40) and few proteins (AAB25244.1, 1EMO_A, Q504W9) as stable (II
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Materials And Methods

Protein Sequence Databases

Protein sequence databases consist of protein sequences and information about proteins. These databases consist of protein sequences that have been translated from the nucleotide sequences and also sequenced by methods like N-terminal sequencing. Many protein sequence databases are available today and all of these databases allow free download of full content. Any researcher from all over the world can download these protein sequences to study the properties of encoded proteins and utilize them for healthcare, disease identification, drug discovery and development. Protein sequence databases contain the amino acid sequence of proteins; the constituent amino acids are represented by single letter amino acid code. Short descriptions of various protein databases used in this study are given in the following sections.

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