Dietary Interventions in Neurodegenerative Diseases: Neuroinflammatory Mechanisms and Implications

Abstract

Neurodegenerative diseases are a broad group of diseases characterized by the loss of structure and function of neuronal cells via various genetic and environmental mechanisms. The basic physiopathology is neuronal integrity disruption by activating intracellular apoptotic mechanisms. The neuronutritional perspective on neurodegenerative diseases has gained importance by discovering the relationship between neuroinflammatory mechanisms and dietary protocols that offer non-invasive treatment options. Gut microbiome imbalance is important for brain-gut pathways. Antiinflammatory diet modeling, one of the non-invasive treatment methods that can reduce neurodegeneration on a disease basis and provide clinical improvement, will contribute to people economically and socially. This chapter provides an overview of the disease-based etiopathogenesis of chronic inflammatory processes underlying various neurodegenerative diseases with available literature data and analyzes the central interactions of different antiinflammatory diet models based on their antiinflammatory mechanisms.