Genomics and Genetics in Cardiovascular Disease

Genomics and Genetics in Cardiovascular Disease

Copyright: © 2015 |Pages: 27
DOI: 10.4018/978-1-4666-8559-8.ch010


This section addresses the origin and relevance of Framingham study to genomic epidemiology of heart disease whereby we explore the economic burden associated with chronic cardiovascular diseases, discuss the gene chromosomes associated with these complex diseases. Besides we accentuate the relevance of the family history approach (FHA) in the identification of intrafamilial risk factors underlying onset of cardiovascular disease and discuss the relevance of the health belief model in sensitizing at-risk groups to participate in primary preventive programs. Finally, we compare the technological and medical diagnostic management of cardiovascular disease in the developed and developing nations, and specify the natural pathways and approaches to heart health.
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Framingham Heart Study: The Legacy For The Genomic Epidemiology Of Cardiovascular Diseases


The Framingham Heart Study (FHS) and the associated legacy transcend medical and epidemiologic sciences. The ramification of Framingham Cardiovascular Study, which was initiated in 1948, has implications that link clinical, social, and behavioral sciences. Besides, it is just an inkling of the multifarious, serendipitous benefits which have been reported by medical scientists and journalists. As a Tuft Medical School Faculty in 1990–1991, a visit to Framingham revealed the suitability of this community for a landmark prospective epidemiological investigation. Owing to the dearth of information about the medical, medical engineering, and genomic interventions derived from the Framingham experience, genomic epidemiology of cardiovascular disease (CVD) will be incomplete.

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