Molecular Interactions of α-Synuclein, Mitochondria, and Cellular Degradation Pathways in Parkinson's Disease

Molecular Interactions of α-Synuclein, Mitochondria, and Cellular Degradation Pathways in Parkinson's Disease

Mansi Verma (Jaypee Institute of Information Technology, India), Sujata Basu (Enago-Publication Support, Crimson Interactive Pvt. Ltd., India), Manisha Singh (Jaypee Institute of Information Technology, India), Rachana R. (Jaypee Institute of Information Technology, India), Simrat Kaur (Jaypee Institute of Information Technology, India) and Neha Goel (Jaypee Institute of Information Technology, India)
Copyright: © 2020 |Pages: 23
DOI: 10.4018/978-1-7998-1317-0.ch008

Abstract

Parkinson's disease (PD) has been reported to be the most common neurodegenerative diseases all over the world. Several proteins are associated and responsible for causing PD. One such protein is α-synuclein. This chapter discusses the role of α-synuclein in PD. Various genetic and epigenetic factors, which cause structural and functional changes for α-synuclein, have been described. Several molecular mechanisms, which are involved in regulating mitochondrial and lysosomal related pathways and are linked to α-synuclein, have been discussed in detail. The knowledge gathered is further discussed in terms of using α-synuclein as a diagnostic marker for PD and as a novel therapeutic target for the same.
Chapter Preview
Top

Structure And Function Of Α-Synuclein In Parkinson’S Disease

α-Syn was first recognized through an antibody used to purify cholinergic vesicles of the torpedo electric organ (Maroteaux and Scheller, 1991)and,α-synuclein involvement in the pre-synaptic functions was first identified. The expression of α-syn was detected by the antibody at the nuclear envelope, along with its localization at the synapse, accounting for its name synuclein (Maroteaux et al., 1988). The presence of α-syn in the nucleus has been accounted for in subsequent research (Gonçalves and Outeiro, 2013, McLean et al., 2000, Mori et al., 2002). Synuclein is a small protein (140 amino acid residues, as shown in Figure 1) which is less than the molecular weight cut off of the nuclear pore (∼40 kDa).

Complete Chapter List

Search this Book:
Reset