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Natural Products Possess Bioactive Agents Investigated for Their Anticancer Potential: Medicinal Importance of Natural Products

Natural Products Possess Bioactive Agents Investigated for Their Anticancer Potential: Medicinal Importance of Natural Products

Kanchi Ravi Padma (Sri Padmavati Mahila Visva Vidyalayam (Women's) University, India) and Kanchi Ravi Don (Shree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, India)
Copyright: © 2022 |Pages: 16
DOI: 10.4018/978-1-7998-9258-8.ch007
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Abstract

Cancer is regarded as a deadly disease and characterized as one of largest problems among the universal population. Worldwide, the population insists on a positive approach for curing the disease. However, plant resources are found to possess multiple phytochemicals which revealed promising effects for various cancer maladies. Over 60% of drugs are obtained from natural source only. Therapy for common cancer involves radiotherapy or chemotherapy, which alters the physical condition of the individual with diverse side effects and ultimately drains the immunity of the individual. Several available drugs are also unable to cure cancer completely, but recent advancement in utilization of plant-based compounds revealed greater beneficial efficacy in management of cancerous cell growth. Therefore, this chapter portrays the bioactive compounds obtained from natural sources and how these traditional medicines act as drug candidates against cancer.
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1. Introduction

Natural products obtained from diverse plant resources have contributed a dominant function in therapy for various maladies. Among them, cancer is in second place and regarded as the most deadliest devastating malady in both developing as well as developed countries. (Lin et al., 2019; Siegel et al., 2020). Due to acceptance of insalubrious lifestyles such as drinking alcohol, smoking eating junk foods with high calorific value, no proper sleep at time, lack of exercise all connected with triggering the incidence of cancer (Jemal et al., 2011). The fundamental cause for increasing deaths around the world which is predictable to be approximately twenty one million by 2030 is none other than cancer (American Cancer Society 2016 and Siegel et al., 2020). (Shown in Table-1)

Table 1.
Estimated New Cases and Deaths for all cancers (GLOBOCAN Statistics 2020)
Site of CancerEstimated New CasesPercentage in all sitesEstimated deathsPercentage in all sites
Lung2,206,77111.41,796,14418.0
Colon1,148,5156.0576,8585.8
Female breast1,261,41911.7684,9966.9
Non melanoma of skin1,198,0736.263,7310.6
Liver905,6774.7830,1808.3
Rectum732,2103.8339,0223.4
Prostate1,414,2597.3375,3043.8
Stomach1,089,1035.6768,7937.7
Vagina17,9080.179950.1
Mesothelioma30,8700.226,2780.3
Kaposi Sarcoma34,2700.215,0860.2
Testis74,4580.493340.1
Hodgkin Lymphoma83,0870.423,3760.2
Anus50,8650.319,2930.2
Vulva45,2400.217,4270.2
Gall bladder115,9490.684,6950.9
Brain, Nervous System308,1021.6251,3292.5
Multiple Myeloma176,4040.9117,0771.2
Nasopharynx133,3540.780,0080.8
Oropharynx98,4120.548,1430.5
Salivary glands53,5830.322,7780.2
Hypopharynx84,2540.438,5990.4
Pancreas495,7732.6466,0034.7
Leukemia474,5192.5311,5942.5
Esophagus604,1003.1544,0765.5
Thyroid586,2023.043,6460.4
Bladder573,2783.0212,5362.1
Cervix uteri604,1273.1341,8313.4
Lip, Oral cavity377,7132.0177,7571.8
Penis36,0680.213,2110.1
Ovary313,9591.6207,2522.1
Melanoma of Skin324,6351.757,0430.6
Corpus Uteri417,3672.297,3701.0
All sites total16,070,5278,668,765

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