Neurosurgical Treatments of Neurodegenerative Disorders

Neurosurgical Treatments of Neurodegenerative Disorders

Carlos Henrique Ferreira Camargo (Hospital Universitário dos Campos Gerais – UEPG, Brazil), Alexandre Novicki Francisco (Pontifícia Universidade Católica do Paraná, Brazil), Alessandra Zanatta (Federal University of Paraná, Brazil), Francisco Manoel Branco Germiniani (Federal University of Paraná, Brazil) and Hélio A. G. Teive (Federal University of Paraná, Brazil)
DOI: 10.4018/978-1-5225-5282-6.ch019
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Functional neurosurgery consists of procedures that either promotes judicious destruction or chronic stimulation of the nervous system in order to treat disordered behavior or aberrant function, as it is expected in neurodegenerative disorders ([NDs], e.g., movement disorders [Parkinson's disease, Tourette's syndrome, essential tremor, ballism, and dystonia]). Over the past 20 years, approximately 100,000 deep brain stimulation implant procedures have been performed worldwide. Neurosurgery is also a well-established therapeutic option for people with epilepsy whose seizures are not controlled by anti-epilepsy drugs. The most common pathological finding in patients with drug-resistant mesial temporal lobe epilepsy is hippocampal sclerosis. The aim of this chapter is to present the main NDs that can be treated through surgical procedures, and to describe the surgeries with a focus on the pathophysiology of diseases.
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The first image about neurosurgery is of a specialty that utilizes surgical techniques aimed at correcting structural / anatomical problems of the nervous system such as aneurysms, brain and spine tumors, fractures and herniated disks. For several years, this type of surgery was the only treatment option available for PD and movement disorders. These procedures were ablative in nature and consisted of surgeries performed on both the peripheral nervous system, including rhizotomies and sympathectomies (Teixeira and Fonoff, 2004), and in the brain, such as corticectomies, trans-ventricular accesses to the basal ganglia nuclei and even section of the cerebral peduncle, procedures that were performed under direct vision and not by a stereotactic approach (Speelman and Bosch, 1998), as the first stereotactic procedures for the treatment of movement disorders would only be performed by Spiegel and Wycis in 1947 (Speelman and Bosch, 1998).

These new perspectives, the “Functional Neurosurgery”, are completely different. Functional neurosurgery consist of procedures that either promote judicious, localized destruction of a target area within the central nervous system, or chronic stimulation of specific structures in order to treat disordered behavior or aberrant function of the nervous system, as it is expected in NDs (Teixeira and Fonoff, 2004).

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