NGS platforms produce a massive amount data (up to terabases) in parallel sequencing method. Often, NGS platforms are classified as second and third generation sequencing technologies. The methods which depends on a PCR step for signal intensification prior to sequencing as next generation sequencing instruments, opposed to single molecule sequencing. Next generation sequencing technology includes the 454 instruments from Roche, the different Illumina platforms and the Life Technologies instruments, i. e. the SOLiD (Sequencing by Oligonucleotide Ligation and Detection) and PacBio RS by Pacific Biosciences. The third generation sequencing instruments like Ion Torrent(PGM=Personal Genome Machine, IonProton) sequencers, MySeq & MsJunior. Next-Generation technology platforms differ in read length, throughput size, data metrics, read depth, etc (Venter et al., 2001; Mardis, 2008).