Protein Folding Classification Through Multicategory Discrete SVM

Protein Folding Classification Through Multicategory Discrete SVM

Carlotta Orsenigo (Università degli Studi di Milano, Italy) and Carlo Vercellis (Università degli Studi di Milano, Italy)
Copyright: © 2008 |Pages: 15
DOI: 10.4018/978-1-59904-528-3.ch007
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In the context of biolife science, predicting the folding structure of a protein plays an important role for investigating its function and discovering new drugs. Protein folding recognition can be naturally cast in the form of a multicategory classification problem, that appears challenging due to the high number of folds classes. Thus, in the last decade several supervised learning methods have been applied in order to discriminate between proteins characterized by different folds. Recently, discrete support vector machines have been introduced as an effective alternative to traditional support vector machines. Discrete SVM have shown to outperform other competing classification techniques both on binary and multicategory benchmark datasets. In this paper, we adopt discrete SVM for protein folding classification. Computational tests performed on benchmark datasets empirically support the effectiveness of discrete SVM, which are able to achieve the highest prediction accuracy.

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