Research Utility of Optical Coherence Tomography (OCT)

Research Utility of Optical Coherence Tomography (OCT)

Konstantinos Toutouzas (Athens Medical School, Greece), Antonios Karanasos (Athens Medical School, Greece) and Christodoulos Stefanadis (Athens Medical School, Greece)
DOI: 10.4018/978-1-61350-095-8.ch013


Within this chapter, the research utility of OCT is detailed. Issues like the potential of OCT for plaque characterization are covered. Additionally, a comparative evaluation of OCT with other invasive imaging techniques, as far as plaque components identification is concerned, is attempted. Finally, the role of OCT for the evaluation of plaque progression is discussed as well as its part in the future research arena.
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Potential Of Oct For Plaque Characterization

A recent pathologic classification of coronary lesions (Virmani, Kolodgie, Burke, Farb, & Schwartz, 2000) distinguishes between non-atherosclerotic intimal lesions and progressive atherosclerotic lesions. The first category consists of intimal thickening and intimal xanthomas, while the latter consists of pathological intimal thickening, fibrous cap atheroma with thin or thick cap, and fibrocalcific plaque. The morphologies of the second category are prone to acute thrombosis amenable to one of three pathological mechanisms: plaque rupture, plaque erosion and calcified nodule. OCT has the potential of imaging all of the aforementioned morphologies and is also capable of imaging thrombosis and distinguishing between fibrin-rich and platelet-rich thrombus.

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