Spatial Omics and Gene Circuits: The Future in Cancer Biology

Abstract

Spatial transcriptomics is a powerful tool in biomedical research that enables the analysis of gene expression patterns within their spatial context. By providing insights into the spatial organisation of gene expression, this technology can help address limitations in the design of synthetic gene circuits in a controlled manner. In cancer biology, combining spatial transcriptomics with other approaches allows researchers to gain a deeper understanding of the spatiotemporal dynamics of gene regulation. This method has significant potential for revealing tissue architecture and cellular heterogeneity, which complements the analysis of gene circuits. This study explores the advantages of spatial transcriptomics and gene circuit analysis, focusing on integrating these techniques to understand better the spatial and temporal regulation of genes within tissues.