Therapeutic Properties of Syzygium cumini (Jamun) and Tinospora cordifolia (Giloy) Against Various Lethal Diseases

Therapeutic Properties of Syzygium cumini (Jamun) and Tinospora cordifolia (Giloy) Against Various Lethal Diseases

Ankita Gautam (Gautam Buddha University, India)
DOI: 10.4018/978-1-6684-3546-5.ch007
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Abstract

Phytochemicals have recently been studied in vivo for their unmatched interactions in curing lethal diseases that can't be cured by allopathic medical intervention without any adverse effect on the patient health. These methods were being used in ancient India, where Jamun and Giloy have been used to decrease hormonal imbalance and pathological disorders. Signaling pathways of the active components of Tinospora cordifolia thus enable effective disease targeting. With so much to offer to the scientific world of medicine, the plant Tinospora truly acts as an incredible source as it deals with seasonal fever like Dengue, Malaria, Chickengunia, and anticancer and anti-HIV (research undergoing). Whereas the Syzygium cumini (Jamun) fruit and seed hold worth in treating various diet-related malfunctions, especially hyperglycemia. In the current research, Jamun seed and fruit extracts have been proved effective in the regulation of blood glucose and insulin parameters.
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Therapeutic Properties

Syzgium Cumini Linn. Skeels Myrtaceae) (Syn. Eugenia Jambolana Lam.)

S. cumini is a large evergreen tropical tree and also known as black plum or jambolan. S. cumini is very well known for their pharmacological properties. The native home of the Syzgium is India and East Indies. The tree fruits once in a year and the berries are sweetish sour to taste. The ripe fruits are used for health drinks, making preserves, squashes, jellies and wine. All parts of the plant especially the seeds are used to treat various diseases, the most important being diabetes mellitus. The medicinal value is due to presence of malic acid (Wealth of India, 2002; Ivan, 2006). Various pharmacological activities of this plant described in table 1.

Gastroprtective and Anti-Ulcerogenic Activities

The gastric mucosal damage was induced in 68 Sprague-Dawley rats by oral gavage administration of HCL/ethanol solution. For investigation, three group were formed, a negative control, an omeprazole group and a tannin group. Microscopic examination using Best’s Ulcer Staging Index showed that tannins had a very significant decrease in gastric mucosal damage. Studies for amount of gastric damage also been carried out it shows lower stomach free radical concentration in rats fed with a dose of 20gm tannins/kg of rat (Ramirez & Roa Jr, 2003).

Anti-Inflammatory Activity

The ethanolic bark extract of S. cumini has been reported to showed anti-inflammatory activity against histamine, serotonin and prostaglandin. Inflammation was induced by individual autacoids insult, Histamine (1mg/mL), serotonin (5-HT, 1mg/mL), bradykinin (0.02mg/mL) and prostaglandin (PGE2, 0.001mg/mL) was used as inflammogens. The ethanolic extract of this plant showed anti-inflammatory effects in histamine, PGE2 and 5-HT induced rat paw oedema (Pandey & Khan, 2002).

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