Unlocking Oceanic Treasures From Marine Metabolites as Potential Therapeutics for Neurodegenerative Diseases

Abstract

Neurodegenerative diseases like Alzheimer's and Parkinson's pose significant challenges due to their progressive nature and limited treatment options. This chapter explores the potential of marine metabolites as therapeutic agents against these debilitating conditions. First, we delve into the diverse array of marine organisms known to produce compounds with neuroprotective properties. Highlighting specific compounds, such as Gracilins, Manzamines, and Fucoidan, we elucidate their mechanisms of action, including inhibition of key enzymes, reduction of neuroinflammation, and promotion of neurogenesis. Marine compounds like Phlorotannins, Bryostatins, and Meridianins show promise in mitigating hallmark pathologies such as tau aggregation and beta-amyloid formation. Additionally, we discuss the potential of marine-derived carotenoids, exemplified by Fucoxanthin, in Parkinson's disease management through their antioxidant and anti-inflammatory effects. Marine metabolites offer a rich source of novel therapeutic compounds for neurodegenerative diseases.