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What is Epigenetics

Encyclopedia of Information Science and Technology, Fourth Edition
The study of heritable changes in gene expression or phenotype that do not arise from changes in the nucleotide sequence of the genome.
Published in Chapter:
Bioinformatics
Mark A. Ragan (The University of Queensland, Australia)
Copyright: © 2018 |Pages: 12
DOI: 10.4018/978-1-5225-2255-3.ch037
Abstract
Bioinformatics has emerged as new discipline at the interface of molecular bioscience with mathematics, computer science and information technology. Bioinformatics is driven by data arising from high-throughput technologies in molecular bioscience. To enable biological discovery, bioinformatics draws on and extends technologies for data capture, management, integration and mining, computing, and communication technology. The rise of genomics has been a key driver for bioinformatics. Genomics, however, was never an end unto itself, but rather was intended to enable the understanding of complex biological systems. Bioinformatics continues to evolve in support of its constituent domains and, increasingly, their integration into genome-scale molecular systems biology. This article presents bioinformatics first from the perspective of computer science and information technology, then from the perspective of bioscience. In practice these perspectives often merge, making bioinformatics a rich, vibrant area of multidisciplinary research and application.
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Current Environmental Health Challenges: Part I - Exposures and Research Trends
The study of heritable phenotype changes in organisms caused by modification of gene expression rather than alteration in the DNA sequence itself.
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Leveraging Literacy Instruction to Support Learners Who Have Experienced Compounded Trauma
The study of how traumatic events and the subsequently triggered behaviors in response to trauma can affect how bodies interpret genetic coding in DNA.
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The Collective Unconscious and the Media Sphere: An Esoteric Analysis of the Disinformation Crisis Facing Western Civilisation
Changes/modifications in the organism that affect gene activity and expression without changing the underlying DNA sequence, and can be passed down by inheritance. May be caused by external conditions (environmental factors such as diet, drugs, media), or as part of normal development. These modifications do not involve alterations of the genetic system of the species, but rather are reflected in new features and behaviors of adaptation, which are transmissible to the next generations (Epigenetics, n.d.; Gaiseanu, 2019a, 2019b).
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Cancer and Signaling Pathway Deregulation
Any biological events that affect the structure or functions of the genome but are not encoded in the DNA, for example, biochemical modifications in the histone proteins entangled in the DNA and DNA methylations.
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Bioinformatics
The study of heritable changes in gene expression or phenotype that do not arise from changes in the nucleotide sequence of the genome.
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Epigenetics
The study of changes in an organism that influences gene expression but are not mediated by the original DNA sequence.
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Personalization 3.0: How Personality Can Predict Consumer Behavior
The study of gene-environment interactions, explaining how the same genotype leads to different phenotypes.
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An In-Depth Analysis of the Bioethical Implications of Stigma: Free v Confined II
The study of how behaviours and environment can change gene expression without altering the DNA sequence.
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Integrating Family History Into the Post-Pandemic Elementary Learning Space: Reducing Childhood Trauma
The study of changes in organisms as a result of modification of gene expression as opposed to the alteration of the genetic code.
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Prediction of Epigenetic Target Sites by Using Genomic DNA Sequence
The study of inherited changes in phenotype or gene expression caused by mechanisms other than changes in the underlying DNA sequence.
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