What is Hydrophobicity

Protein folding has played a vital role in rational drug design, pharmacology and many other applications. The knowledge of protein structural class provides useful information towards the determination of protein structure. The exponential growth of newly discovered protein sequences by different scientific communities has made a large gap between the number of sequence-known and the number of structure-known proteins. Accurate determination of protein structural class using a suitable computational method has been a challenging problem in protein science. This chapter is based on the concept of Chou's pseudo amino acid composition feature representation method. Thus the sample of a protein is represented by a set of discrete components which incorporate both the sequence order and the length effect. On the basis of such a statistical framework a low complexity functional link artificial neural network and a complex novel hybrid model using radial basis function neural network and multi-objective algorithm based classifier are introduced to predict protein structural class.