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What is Hydroxyurea

Chapter 9
Cases on Communication Disorders in Culturally Diverse Populations
Hydroxyurea, a myelosuppressive agent, is the only effective drug proven to reduce the frequency of painful episodes in sickle cell disease. It raises the level of fetal hemoglobin (HbF). It usually decreases the rate of painful episodes by 50%. It was first tested in SCD in 1984. It was developed as an anticancer drug and has been used to treat myeloproliferative syndromes such as leukemia, melanoma, and ovarian cancer (CDC, 2019 AU50: The in-text citation "CDC, 2019" is not in the reference list. Please correct the citation, add the reference to the list, or delete the citation. ).
Published in Chapter:
Sickle Cell Disease and Hidden Hearing Loss
Diane M. Scott (North Carolina Central University, USA)
Copyright: © 2020 |Pages: 15
DOI: 10.4018/978-1-7998-2261-5.ch009
Abstract
Sickle cell disease (SCD) is an autosomal recessively inherited group of red blood cell disorders. It is more commonly found in African Americans and Hispanics in the United States. The sickle-shaped cells characteristic of the disease cause physiological problems, including hemolytic anemia and vaso-occlusion. Research has linked hearing loss to sickle cell disease. Studies have shown that children and adults with sickle cell disease may have higher rates of sensorineural and central auditory hearing impairment. This case study examines hidden hearing loss in an African American boy with SCD who presents with normal hearing thresholds. It also discusses the role of audiologists in the care of individuals with sickle cell disease and hearing loss.
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