What is K-Means Clustering

This chapter introduces the techniques that have been used to identify the genetic regulatory modules by integrating data from various sources. Data relating to the functioning of individual genes can be drawn from many different and diverse experimental techniques. Each piece of data provides information on a specific aspect of the cell regulation process. The chapter argues that integration of these diverse types of data is essential in order to identify biologically relevant regulatory modules. A concise review of the different integration techniques is presented, together with a critical discussion of their pros and cons. A very large number of research papers have been published on this topic, and the authors hope that this chapter will present the reader with a high-level view of the area, elucidating the research issues and underlining the importance of data integration in modern bioinformatics.