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What is Metabolic Pathways

Chapter 27
Handbook of Research on Systems Biology Applications in Medicine
A metabolic pathway is any sequence of feasible and observable biochemical reaction steps catalysed by enzymes and connecting a specified set of input and output metabolites.
Published in Chapter:
Applications of Metabolic Flux Balancing in Medicine
Ferda Mavituna (The University of Manchester, UK), Raul Munoz-Hernandez (The University of Manchester, UK), and Ana Katerine de Carvalho Lima Lobato (Federal University of Rio Grande do Norte, Brazil, and Potiguar University, Brazil)
Copyright: © 2009 |Pages: 17
DOI: 10.4018/978-1-60566-076-9.ch027
Abstract
This chapter summarizes the fundamentals of metabolic flux balancing as a computational tool of metabolic engineering and systems biology. It also presents examples from the literature for its applications in medicine. These examples involve mainly liver metabolism and antibiotic production. Metabolic flux balancing is a computational method for the determination of metabolic pathway fluxes through a stoichiometric model of the cellular pathways, using mass balances for intracellular metabolites. It is a powerful tool to study metabolism under normal and abnormal conditions with a view to engineer the metabolism. Its extended potential in medicine is emphasized in the future trends.
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