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What is Mosaicism

Encyclopedia of Information Science and Technology, Fifth Edition
A condition in which cells within the same person have a different genetic makeup.
Published in Chapter:
Gene Editing Technology and Ethical Issues
Barbara Jane Holland (Brooklyn Public Library, USA (retired) & Independent Researcher, USA)
Copyright: © 2021 |Pages: 15
DOI: 10.4018/978-1-7998-3479-3.ch136
Abstract
CRISPR (clustered regularly interspaced short palindromic repeats) technology has emerged as a powerful technology for genome editing and is now widely used in basic biomedical research to explore gene function. More recently, this technology has been increasingly applied to the study or treatment of human diseases. CRISPR/Cas9 gene editing has also been applied in immunology-focused applications such as the targeting of C-C chemokine receptor type 5, the programmed death 1 gene and the creation of chimeric antigen receptors in T cells for purposes such as the treatment of the acquired immune deficiency syndrome (AIDS) or promoting anti-tumor immunotherapy. Furthermore, scientist recently suggest through their study that CRISPR may not work for everyone. This paper will review gene editing technology and its ethical concerns.
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