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What is Non-Covalent Interactions

Chapter 14
Handbook of Research on Computational and Systems Biology: Interdisciplinary Applications
Weak energetic contributions arising from hydrogen bonds, hydrophobic interactions, ionic bonds and van der Waals forces that work in combinations. They are characteristic of macromolecular interactions such as protein-protein and protein-nucleic acids. Intramolecular non-covalent interactions are responsible for the secondary and tertiary structure of proteins and for holding together the two strands of double helical DNA.
Published in Chapter:
Pathway Resources at the Rat Genome Database: A Dynamic Platform for Integrating Gene, Pathway and Disease Information
Victoria Petri (Medical College of Wisconsin, USA)
Copyright: © 2011 |Pages: 21
DOI: 10.4018/978-1-60960-491-2.ch014
Abstract
The set of interacting molecules representing a biological pathway or network is a central concept in biology. It is within the pathway context that the functioning of individual molecules acquires purpose and it is the integration of these molecular circuitries that underlies the functioning of biological systems. In order to provide the research community with a dynamic platform for accessing pathway information, the Rat Genome Database (RGD – http://rgd.mcw.edu) is using a multi-tiered approach. In this chapter, the pathway resources that RGD currently offers are presented. Issues covered include: the biological pathway, the concept and the ontology, pathway literature curation and annotation of genes, interactive pathway diagrams, and tools and resources to access and navigate between pathway data. A case study is presented; future directions are discussed.
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