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What is Orthogonal Life

Handbook of Research on Systems Biology Applications in Medicine
A term stressing the complete isolation of artificial life-like creatures from natural processes by using the alternative genetic code and the reliable interface. Chen’s rules should be taken in an account: 1) nanomachines should only be specialized, not general purpose, 2) nanomachines should not be self-replicating, 3) nanomachines should not be made to use an abundant natural compound as fuel, 4) nanomachines should be tagged so they can be tracked.
Published in Chapter:
Synthetic Biology as a Proof of Systems Biology
Andrew Kuznetsov (Freiburg University, Germany)
Copyright: © 2009 |Pages: 19
DOI: 10.4018/978-1-60566-076-9.ch005
Abstract
Biologists have used a reductionist approach to investigate the essence of life. In the last years, scientific disciplines have merged with the aim of studying life on a global scale in terms of molecules and their interactions. Based on high-throughput measurements, Systems Biology adopts mathematical modeling and computational simulation to reconstruct natural biological systems. Synthetic Biology seeks to engineer artificial biological systems starting from standard molecular compounds coding in DNA. Can Systems and Synthetic Biology be combined with the idea of creating a new science—‘SYS Biology’ that will not demarcate natural and artificial realities? What will this approach bring to medicine?
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