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What is Protein Complexes

Chapter 39
Handbook of Research on Systems Biology Applications in Medicine
Protein complex is a group of two or more associated proteins, formed by protein-protein interaction. It is usually stable over time and it is a form of quaternary structure.
Published in Chapter:
Protein Interactions and Diseases
Athina Theodosiou (Biomedical Research Foundation of the Academy of Athens, Greece), Charalampos Moschopoulos (Biomedical Research Foundation of the Academy of Athens, Greece), Marc Baumann (Biomedicum, Helsinki University, Finland), and Sophia Kossida (Biomedical Research Foundation of the Academy of Athens, Greece)
Copyright: © 2009 |Pages: 20
DOI: 10.4018/978-1-60566-076-9.ch039
Abstract
In previous years, scientists have begun understanding the significance of proteins and protein interactions. The direct connection of those with human diseases is now unquestionable and proteomics have become a scientific section of great research interest. In this chapter, we present a detailed description of the nature of protein interactions and describe the more important methodologies that are being used for their detection. Moreover, we review the mechanisms leading to diseases and involving protein interactions and refer to specific diseases such as Huntington’s disease and cancer. Lastly, we give an overview of the most popular computational methods that are used for the prediction or the healing of the diseases.
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