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Large-Scale Co-Phylogenetic Analysis on the Grid

Large-Scale Co-Phylogenetic Analysis on the Grid

Heinz Stockinger, Alexander Auch, Markus Goeker, Jan Meier-Kolthoff, Alexandros Stamatakis
Copyright: © 2009 |Pages: 15
ISBN13: 9781605663746|ISBN10: 1605663743|EISBN13: 9781605663753
DOI: 10.4018/978-1-60566-374-6.ch035
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MLA

Stockinger, Heinz, et al. "Large-Scale Co-Phylogenetic Analysis on the Grid." Handbook of Research on Computational Grid Technologies for Life Sciences, Biomedicine, and Healthcare, edited by Mario Cannataro, IGI Global, 2009, pp. 731-745. https://doi.org/10.4018/978-1-60566-374-6.ch035

APA

Stockinger, H., Auch, A., Goeker, M., Meier-Kolthoff, J., & Stamatakis, A. (2009). Large-Scale Co-Phylogenetic Analysis on the Grid. In M. Cannataro (Ed.), Handbook of Research on Computational Grid Technologies for Life Sciences, Biomedicine, and Healthcare (pp. 731-745). IGI Global. https://doi.org/10.4018/978-1-60566-374-6.ch035

Chicago

Stockinger, Heinz, et al. "Large-Scale Co-Phylogenetic Analysis on the Grid." In Handbook of Research on Computational Grid Technologies for Life Sciences, Biomedicine, and Healthcare, edited by Mario Cannataro, 731-745. Hershey, PA: IGI Global, 2009. https://doi.org/10.4018/978-1-60566-374-6.ch035

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Abstract

Phylogenetic data analysis represents an extremely compute-intensive area of Bioinformatics and thus requires high-performance technologies. Another compute- and memory-intensive problem is that of host-parasite co-phylogenetic analysis: given two phylogenetic trees, one for the hosts (e.g., mammals) and one for their respective parasites (e.g., lice) the question arises whether host and parasite trees are more similar to each other than expected by chance alone. CopyCat is an easy-to-use tool that allows biologists to conduct such co-phylogenetic studies within an elaborate statistical framework based on the highly optimized sequential and parallel AxParafit program. We have developed enhanced versions of these tools that efficiently exploit a Grid environment and therefore facilitate large-scale data analyses. Furthermore, we developed a freely accessible client tool that provides co-phylogenetic analysis capabilities. Since the computational bulk of the problem is embarrassingly parallel, it fits well to a computational Grid and reduces the response time of large scale analyses.

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