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Predicting Protein Functions from Protein Interaction Networks

Predicting Protein Functions from Protein Interaction Networks

Hon Nian Chua, Limsoon Wong
Copyright: © 2012 |Volume: 3 |Issue: 4 |Pages: 21
ISSN: 1947-9115|EISSN: 1947-9123|EISBN13: 9781466613249|DOI: 10.4018/ijkdb.2012100104
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MLA

Chua, Hon Nian, and Limsoon Wong. "Predicting Protein Functions from Protein Interaction Networks." IJKDB vol.3, no.4 2012: pp.50-70. http://doi.org/10.4018/ijkdb.2012100104

APA

Chua, H. N. & Wong, L. (2012). Predicting Protein Functions from Protein Interaction Networks. International Journal of Knowledge Discovery in Bioinformatics (IJKDB), 3(4), 50-70. http://doi.org/10.4018/ijkdb.2012100104

Chicago

Chua, Hon Nian, and Limsoon Wong. "Predicting Protein Functions from Protein Interaction Networks," International Journal of Knowledge Discovery in Bioinformatics (IJKDB) 3, no.4: 50-70. http://doi.org/10.4018/ijkdb.2012100104

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Abstract

Functional characterization of genes and their protein products is essential to biological and clinical research. Yet, there is still no reliable way of assigning functional annotations to proteins in a high-throughput manner. In this article, the authors provide an introduction to the task of automated protein function prediction. They discuss about the motivation for automated protein function prediction, the challenges faced in this task, as well as some approaches that are currently available. In particular, they take a closer look at methods that use protein-protein interaction for protein function prediction, elaborating on their underlying techniques and assumptions, as well as their strengths and limitations.

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