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Spatial Heart Simulation and Adaptive Wave Propagation

Spatial Heart Simulation and Adaptive Wave Propagation

Sándor Miklós Szilágyi, László Szilágyi, Attila Frigy, Levente Gorog, Zoltán Benyó
Copyright: © 2008 |Pages: 8
ISBN13: 9781599048895|ISBN10: 1599048892|EISBN13: 9781599048901
DOI: 10.4018/978-1-59904-889-5.ch157
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MLA

Szilágyi, Sándor Miklós, et al. "Spatial Heart Simulation and Adaptive Wave Propagation." Encyclopedia of Healthcare Information Systems, edited by Nilmini Wickramasinghe and Eliezer Geisler, IGI Global, 2008, pp. 1253-1260. https://doi.org/10.4018/978-1-59904-889-5.ch157

APA

Szilágyi, S. M., Szilágyi, L., Frigy, A., Gorog, L., & Benyó, Z. (2008). Spatial Heart Simulation and Adaptive Wave Propagation. In N. Wickramasinghe & E. Geisler (Eds.), Encyclopedia of Healthcare Information Systems (pp. 1253-1260). IGI Global. https://doi.org/10.4018/978-1-59904-889-5.ch157

Chicago

Szilágyi, Sándor Miklós, et al. "Spatial Heart Simulation and Adaptive Wave Propagation." In Encyclopedia of Healthcare Information Systems, edited by Nilmini Wickramasinghe and Eliezer Geisler, 1253-1260. Hershey, PA: IGI Global, 2008. https://doi.org/10.4018/978-1-59904-889-5.ch157

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Abstract

Sudden cardiac death, caused mostly by ventricular fibrillation, is responsible for at least five million deaths in the world each year. Despite decades of research, the mechanisms responsible for ventricular fibrillation are not well understood. As most computational studies are limited primarily to planar simulations, experiments so far have not elucidated the mechanisms responsible for spatial phenomenon (Janse, Wilms-Schopman, & Coronel, 1995) of ventricular fibrillation. It would be important to understand how the onset of arrhythmias that cause fibrillation depends on details such as heart size (Winfree, 1994), geometry (Vetter & McCulloch, 1998; Panfilov, 1999), mechanical and electrical state, anisotropic fiber structure (Fenton & Karma, 1998), and inhomogeneities (Antzelevitch et al., 1999; Wolk, Cobbe, Hicks, & Kane, 1999). The main difficulty in development of a quantitatively accurate simulation of an entire three-dimensional human heart is that human heart muscle is a strongly excitable medium whose electrical dynamics involve rapidly varying, highly localized fronts (Cherry, Greenside, & Henriquez, 2000).

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