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Role of Epigenetics in Cancer Genomics

Role of Epigenetics in Cancer Genomics

Amit Nagal
Copyright: © 2016 |Pages: 13
ISBN13: 9781466687264|ISBN10: 1466687266|EISBN13: 9781466687271
DOI: 10.4018/978-1-4666-8726-4.ch011
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MLA

Nagal, Amit. "Role of Epigenetics in Cancer Genomics." Software Innovations in Clinical Drug Development and Safety, edited by Partha Chakraborty and Amit Nagal, IGI Global, 2016, pp. 234-246. https://doi.org/10.4018/978-1-4666-8726-4.ch011

APA

Nagal, A. (2016). Role of Epigenetics in Cancer Genomics. In P. Chakraborty & A. Nagal (Eds.), Software Innovations in Clinical Drug Development and Safety (pp. 234-246). IGI Global. https://doi.org/10.4018/978-1-4666-8726-4.ch011

Chicago

Nagal, Amit. "Role of Epigenetics in Cancer Genomics." In Software Innovations in Clinical Drug Development and Safety, edited by Partha Chakraborty and Amit Nagal, 234-246. Hershey, PA: IGI Global, 2016. https://doi.org/10.4018/978-1-4666-8726-4.ch011

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Abstract

Epigenetics is the study of changes in organisms caused by modification of gene expression rather than alteration of the genetic code itself. ChIP-seq, is a method used to analyze protein interactions with DNA. It is a type of epigenetic analysis technique. Chromatin immunoprecipitation coupled with massive parallel sequencing (ChIP-seq) is gaining popularity day by day because of its clinical significance. It is a very effective tool in diagnosis of disease such as cancer. ChIP-seq is found to be very effective tool in understanding basic regulatory mechanism, cell differentiation study and studying disease processes with the decreasing cost of sequencing, ChIP-seq has become an indispensable tool for studying gene regulation and epigenetic mechanisms. The Present review explores epigenetic methods, pipeline and its role in cancer.

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