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Development of Novel Multi-Objective Based Model for Protein Structural Class Prediction

Development of Novel Multi-Objective Based Model for Protein Structural Class Prediction

Bishnupriya Panda, Babita Majhi
Copyright: © 2016 |Pages: 32
ISBN13: 9781522504276|ISBN10: 1522504273|EISBN13: 9781522504283
DOI: 10.4018/978-1-5225-0427-6.ch005
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MLA

Panda, Bishnupriya, and Babita Majhi. "Development of Novel Multi-Objective Based Model for Protein Structural Class Prediction." Handbook of Research on Computational Intelligence Applications in Bioinformatics, edited by Sujata Dash and Bidyadhar Subudhi, IGI Global, 2016, pp. 76-107. https://doi.org/10.4018/978-1-5225-0427-6.ch005

APA

Panda, B. & Majhi, B. (2016). Development of Novel Multi-Objective Based Model for Protein Structural Class Prediction. In S. Dash & B. Subudhi (Eds.), Handbook of Research on Computational Intelligence Applications in Bioinformatics (pp. 76-107). IGI Global. https://doi.org/10.4018/978-1-5225-0427-6.ch005

Chicago

Panda, Bishnupriya, and Babita Majhi. "Development of Novel Multi-Objective Based Model for Protein Structural Class Prediction." In Handbook of Research on Computational Intelligence Applications in Bioinformatics, edited by Sujata Dash and Bidyadhar Subudhi, 76-107. Hershey, PA: IGI Global, 2016. https://doi.org/10.4018/978-1-5225-0427-6.ch005

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Abstract

Protein folding has played a vital role in rational drug design, pharmacology and many other applications. The knowledge of protein structural class provides useful information towards the determination of protein structure. The exponential growth of newly discovered protein sequences by different scientific communities has made a large gap between the number of sequence-known and the number of structure-known proteins. Accurate determination of protein structural class using a suitable computational method has been a challenging problem in protein science. This chapter is based on the concept of Chou's pseudo amino acid composition feature representation method. Thus the sample of a protein is represented by a set of discrete components which incorporate both the sequence order and the length effect. On the basis of such a statistical framework a low complexity functional link artificial neural network and a complex novel hybrid model using radial basis function neural network and multi-objective algorithm based classifier are introduced to predict protein structural class.

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