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Vesicular Drug Delivery Systems: A Special Emphasis on Pharmacosomes

Vesicular Drug Delivery Systems: A Special Emphasis on Pharmacosomes

Preeti Khulbe
Copyright: © 2017 |Pages: 27
ISBN13: 9781522507512|ISBN10: 1522507515|EISBN13: 9781522507529
DOI: 10.4018/978-1-5225-0751-2.ch005
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MLA

Khulbe, Preeti. "Vesicular Drug Delivery Systems: A Special Emphasis on Pharmacosomes." Novel Approaches for Drug Delivery, edited by Raj K. Keservani, et al., IGI Global, 2017, pp. 121-147. https://doi.org/10.4018/978-1-5225-0751-2.ch005

APA

Khulbe, P. (2017). Vesicular Drug Delivery Systems: A Special Emphasis on Pharmacosomes. In R. Keservani, A. Sharma, & R. Kesharwani (Eds.), Novel Approaches for Drug Delivery (pp. 121-147). IGI Global. https://doi.org/10.4018/978-1-5225-0751-2.ch005

Chicago

Khulbe, Preeti. "Vesicular Drug Delivery Systems: A Special Emphasis on Pharmacosomes." In Novel Approaches for Drug Delivery, edited by Raj K. Keservani, Anil K. Sharma, and Rajesh Kumar Kesharwani, 121-147. Hershey, PA: IGI Global, 2017. https://doi.org/10.4018/978-1-5225-0751-2.ch005

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Abstract

Pharmacosomes are the colloidal dispersions of drugs covalently bound to lipids and may exist as ultrafine vesicular, micellar or hexagonal aggregates, depending on the chemical structure of the drug lipid complex. The term pharmacosomes is explicitly used to describe the zwitterion, amphiphilic stoichiometric complexes of polyphenolic compounds with phospholipids. The system is formed by linking a drug (pharmakon) to a carrier (soma), they are called pharmacosomes. Pharmacosomes can pass through biomembranes efficiently and possess advantages over the use of other vesicular systems such as transferosomes liposomes and noisome. Pharmacososmes are design to avoid the unusual problems associated with the liposomal entrapment of polar drug molecules like low drug incorporation, leakage and solubility. This chapter includes the basic introduction, applications, method of preparation, characterisation, advantages, some research experiences and future prospects of pharmacosomes.

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