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Engineered Gellan Polysaccharides in the Design of Controlled Drug Delivery Systems

Engineered Gellan Polysaccharides in the Design of Controlled Drug Delivery Systems

Sabyasachi Maiti
Copyright: © 2017 |Pages: 28
ISBN13: 9781522517627|ISBN10: 1522517626|EISBN13: 9781522517634
DOI: 10.4018/978-1-5225-1762-7.ch010
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MLA

Maiti, Sabyasachi. "Engineered Gellan Polysaccharides in the Design of Controlled Drug Delivery Systems." Pharmaceutical Sciences: Breakthroughs in Research and Practice, edited by Information Resources Management Association, IGI Global, 2017, pp. 246-273. https://doi.org/10.4018/978-1-5225-1762-7.ch010

APA

Maiti, S. (2017). Engineered Gellan Polysaccharides in the Design of Controlled Drug Delivery Systems. In I. Management Association (Ed.), Pharmaceutical Sciences: Breakthroughs in Research and Practice (pp. 246-273). IGI Global. https://doi.org/10.4018/978-1-5225-1762-7.ch010

Chicago

Maiti, Sabyasachi. "Engineered Gellan Polysaccharides in the Design of Controlled Drug Delivery Systems." In Pharmaceutical Sciences: Breakthroughs in Research and Practice, edited by Information Resources Management Association, 246-273. Hershey, PA: IGI Global, 2017. https://doi.org/10.4018/978-1-5225-1762-7.ch010

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Abstract

Natural polysaccharides are getting increasing attention in the development of pharmaceutical dosage forms due to their encouraging reports on nontoxicity and biodegradability. Natural gums can also be engineered to have better materials for drug delivery system design. Gellan gum originates from microbial fermentation and has been declared as safe by US FDA for human consumption. It possesses gelling ability in presence of multivalent earth metal cations and thus enabled the design of mutiparticulate drug delivery systems in completely aqueous environment avoiding the use of organic solvents. Due to faster drug release profiles of divalent cation-induced gellan gum particles, nowadays chemically modified forms of gellan polysaccharide are currently being investigated for the controlled release of drugs. This chapter discusses the factors contributing to the varying gelling characteristics of gellan gum and the recent developments in its chemical modification towards the fabrication of novel controlled drug delivery devices.

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