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Mineralized Nanofibers for Bone Tissue Engineering

Mineralized Nanofibers for Bone Tissue Engineering

Ozan Karaman
Copyright: © 2018 |Pages: 15
ISBN13: 9781522531586|ISBN10: 1522531580|EISBN13: 9781522531593
DOI: 10.4018/978-1-5225-3158-6.ch020
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MLA

Karaman, Ozan. "Mineralized Nanofibers for Bone Tissue Engineering." Biomedical Engineering: Concepts, Methodologies, Tools, and Applications, edited by Information Resources Management Association, IGI Global, 2018, pp. 461-475. https://doi.org/10.4018/978-1-5225-3158-6.ch020

APA

Karaman, O. (2018). Mineralized Nanofibers for Bone Tissue Engineering. In I. Management Association (Ed.), Biomedical Engineering: Concepts, Methodologies, Tools, and Applications (pp. 461-475). IGI Global. https://doi.org/10.4018/978-1-5225-3158-6.ch020

Chicago

Karaman, Ozan. "Mineralized Nanofibers for Bone Tissue Engineering." In Biomedical Engineering: Concepts, Methodologies, Tools, and Applications, edited by Information Resources Management Association, 461-475. Hershey, PA: IGI Global, 2018. https://doi.org/10.4018/978-1-5225-3158-6.ch020

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Abstract

The limitation of orthopedic fractures and large bone defects treatments has brought the focus on fabricating bone grafts that could enhance ostegenesis and vascularization in-vitro. Developing biomimetic materials such as mineralized nanofibers that can provide three-dimensional templates of the natural bone extracellular-matrix is one of the most promising alternative for bone regeneration. Understanding the interactions between the structure of the scaffolds and cells and therefore the control cellular pathways are critical for developing functional bone grafts. In order to enhance bone regeneration, the engineered scaffold needs to mimic the characteristics of composite bone ECM. This chapter reviews the fabrication of and fabrication techniques for fabricating biomimetic bone tissue engineering scaffolds. In addition, the chapter covers design criteria for developing the scaffolds and examples of enhanced osteogenic differentiation outcomes by fabricating biomimetic scaffolds.

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