Analyzing Interval Systems of Human T-Cell Lymphotropic Virus Type I Infection of CD4+ T-Cells

Analyzing Interval Systems of Human T-Cell Lymphotropic Virus Type I Infection of CD4+ T-Cells

Zohreh Dadi
ISBN13: 9781522525158|ISBN10: 1522525157|EISBN13: 9781522525165
DOI: 10.4018/978-1-5225-2515-8.ch006
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MLA

Dadi, Zohreh. "Analyzing Interval Systems of Human T-Cell Lymphotropic Virus Type I Infection of CD4+ T-Cells." Handbook of Research on Data Science for Effective Healthcare Practice and Administration, edited by Elham Akhond Zadeh Noughabi, et al., IGI Global, 2017, pp. 126-147. https://doi.org/10.4018/978-1-5225-2515-8.ch006

APA

Dadi, Z. (2017). Analyzing Interval Systems of Human T-Cell Lymphotropic Virus Type I Infection of CD4+ T-Cells. In E. Noughabi, B. Raahemi, A. Albadvi, & B. Far (Eds.), Handbook of Research on Data Science for Effective Healthcare Practice and Administration (pp. 126-147). IGI Global. https://doi.org/10.4018/978-1-5225-2515-8.ch006

Chicago

Dadi, Zohreh. "Analyzing Interval Systems of Human T-Cell Lymphotropic Virus Type I Infection of CD4+ T-Cells." In Handbook of Research on Data Science for Effective Healthcare Practice and Administration, edited by Elham Akhond Zadeh Noughabi, et al., 126-147. Hershey, PA: IGI Global, 2017. https://doi.org/10.4018/978-1-5225-2515-8.ch006

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Abstract

Human T-cell lymphotropic virus type I (HTLV-I) infects a type of white blood cell called a T lymphocyte. HTLV-I infection is seen in diverse region of the world such as the Caribbean Islands, southwestern Japan, southeastern United States, and Mashhad (Iran). This virus is the etiological agent of two main types of disease: HTLV-I-associated myelopathy/tropical spastic paraparesis and adult T cell leukemia. Also, the role of HTLV-I in the pathogenesis of autoimmune diseases such as HTLV-I associated arthropathy and systemic lupus erythematosus is under investigation. In this chapter, the author considers an ODE model of T-cell dynamics in HTLV-I infection which was proposed by Stilianakis and Seydel in 1999. Mathematical analysis of the model with fixed parameters has been done by many researchers. The author studies dynamical behavior (local stability) of this model with interval uncertainties, called interval system. Also, effective parameters in the local dynamics of model are found. For this study, interval analysis and particularly of Kharitonov's stability theorem are used.

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