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Therapeutic Enzymes Used for the Treatment of Cardiovascular Diseases and Coagulation Disorders

Therapeutic Enzymes Used for the Treatment of Cardiovascular Diseases and Coagulation Disorders

Abderrezak Khelfi
Copyright: © 2018 |Pages: 23
ISBN13: 9781522552376|ISBN10: 1522552375|EISBN13: 9781522552383
DOI: 10.4018/978-1-5225-5237-6.ch002
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MLA

Khelfi, Abderrezak. "Therapeutic Enzymes Used for the Treatment of Cardiovascular Diseases and Coagulation Disorders." Research Advancements in Pharmaceutical, Nutritional, and Industrial Enzymology, edited by Shashi Lata Bharati and Pankaj Kumar Chaurasia, IGI Global, 2018, pp. 23-45. https://doi.org/10.4018/978-1-5225-5237-6.ch002

APA

Khelfi, A. (2018). Therapeutic Enzymes Used for the Treatment of Cardiovascular Diseases and Coagulation Disorders. In S. Bharati & P. Chaurasia (Eds.), Research Advancements in Pharmaceutical, Nutritional, and Industrial Enzymology (pp. 23-45). IGI Global. https://doi.org/10.4018/978-1-5225-5237-6.ch002

Chicago

Khelfi, Abderrezak. "Therapeutic Enzymes Used for the Treatment of Cardiovascular Diseases and Coagulation Disorders." In Research Advancements in Pharmaceutical, Nutritional, and Industrial Enzymology, edited by Shashi Lata Bharati and Pankaj Kumar Chaurasia, 23-45. Hershey, PA: IGI Global, 2018. https://doi.org/10.4018/978-1-5225-5237-6.ch002

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Abstract

The successful introduction of enzyme replacement therapy opened the way for the use of enzymes, first as crude preparations and later as highly purified enzymes for use in cardiovascular diseases, clotting disorders, etc. Elimination of blood clot is the key factor in thrombolytic therapy and fibrinolytic enzyme therapy can be practiced to remove the clot. Based on the mechanism of action, they are of two types of enzymes: plasminogen activators and plasmin-like enzymes. Plasma products are usually employed as a source of several enzymes used for the treatment of coagulation disorders. While these products have traditionally been purified from blood donations and obtained as foreign proteins obtained from heterogeneous sources, most are now produced by biotechnology. The therapeutic enzymes reviewed in this chapter are used for the treatment of cardiovascular diseases and hereditary diseases leading to coagulation disorders. Enzyme preparations obtained by direct fractionation from a naturally producing source and recombinant enzymes are considered in this chapter.

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