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Alternative Isoform Detection Using Exon Arrays

Alternative Isoform Detection Using Exon Arrays

Jacek Majewski
Copyright: © 2009 |Pages: 16
ISBN13: 9781605660769|ISBN10: 1605660760|EISBN13: 9781605660776
DOI: 10.4018/978-1-60566-076-9.ch015
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MLA

Majewski, Jacek. "Alternative Isoform Detection Using Exon Arrays." Handbook of Research on Systems Biology Applications in Medicine, edited by Andriani Daskalaki , IGI Global, 2009, pp. 262-277. https://doi.org/10.4018/978-1-60566-076-9.ch015

APA

Majewski, J. (2009). Alternative Isoform Detection Using Exon Arrays. In A. Daskalaki (Ed.), Handbook of Research on Systems Biology Applications in Medicine (pp. 262-277). IGI Global. https://doi.org/10.4018/978-1-60566-076-9.ch015

Chicago

Majewski, Jacek. "Alternative Isoform Detection Using Exon Arrays." In Handbook of Research on Systems Biology Applications in Medicine, edited by Andriani Daskalaki , 262-277. Hershey, PA: IGI Global, 2009. https://doi.org/10.4018/978-1-60566-076-9.ch015

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Abstract

Eukaryotic genes have the ability to produce several distinct products from a single genomic locus. Recent developments in microarray technology allow monitoring of such isoform variation at a genome-wide scale. In our research, we have used Affymetrix Exon Arrays to detect variation in alternative splicing, initiation of transcription, and polyadenylation among humans. We demonstrated that such variation is common in human populations and has an underlying genetic component. Here, we use our study to illustrate the use of Exon Arrays to detect alternative isoforms, to outline the analysis involved, and to point out potential problems that may be encountered by researchers using this technology.

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