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Applications of Metabolic Flux Balancing in Medicine

Applications of Metabolic Flux Balancing in Medicine

Ferda Mavituna, Raul Munoz-Hernandez, Ana Katerine de Carvalho Lima Lobato
Copyright: © 2009 |Pages: 17
ISBN13: 9781605660769|ISBN10: 1605660760|EISBN13: 9781605660776
DOI: 10.4018/978-1-60566-076-9.ch027
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MLA

Mavituna, Ferda, et al. "Applications of Metabolic Flux Balancing in Medicine." Handbook of Research on Systems Biology Applications in Medicine, edited by Andriani Daskalaki , IGI Global, 2009, pp. 458-474. https://doi.org/10.4018/978-1-60566-076-9.ch027

APA

Mavituna, F., Munoz-Hernandez, R., & de Carvalho Lima Lobato, A. K. (2009). Applications of Metabolic Flux Balancing in Medicine. In A. Daskalaki (Ed.), Handbook of Research on Systems Biology Applications in Medicine (pp. 458-474). IGI Global. https://doi.org/10.4018/978-1-60566-076-9.ch027

Chicago

Mavituna, Ferda, Raul Munoz-Hernandez, and Ana Katerine de Carvalho Lima Lobato. "Applications of Metabolic Flux Balancing in Medicine." In Handbook of Research on Systems Biology Applications in Medicine, edited by Andriani Daskalaki , 458-474. Hershey, PA: IGI Global, 2009. https://doi.org/10.4018/978-1-60566-076-9.ch027

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Abstract

This chapter summarizes the fundamentals of metabolic flux balancing as a computational tool of metabolic engineering and systems biology. It also presents examples from the literature for its applications in medicine. These examples involve mainly liver metabolism and antibiotic production. Metabolic flux balancing is a computational method for the determination of metabolic pathway fluxes through a stoichiometric model of the cellular pathways, using mass balances for intracellular metabolites. It is a powerful tool to study metabolism under normal and abnormal conditions with a view to engineer the metabolism. Its extended potential in medicine is emphasized in the future trends.

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