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Fluorescence Imaging of Mitochondrial Long-Term Depolarization in Cancer Cells Exposed to Heat-Stress

Fluorescence Imaging of Mitochondrial Long-Term Depolarization in Cancer Cells Exposed to Heat-Stress

Cathrin Dressler, Olaf Minet, Urszula Zabarylo, Jürgen Beuthan
Copyright: © 2009 |Pages: 20
ISBN13: 9781605660769|ISBN10: 1605660760|EISBN13: 9781605660776
DOI: 10.4018/978-1-60566-076-9.ch038
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MLA

Dressler, Cathrin, et al. "Fluorescence Imaging of Mitochondrial Long-Term Depolarization in Cancer Cells Exposed to Heat-Stress." Handbook of Research on Systems Biology Applications in Medicine, edited by Andriani Daskalaki , IGI Global, 2009, pp. 673-692. https://doi.org/10.4018/978-1-60566-076-9.ch038

APA

Dressler, C., Minet, O., Zabarylo, U., & Beuthan, J. (2009). Fluorescence Imaging of Mitochondrial Long-Term Depolarization in Cancer Cells Exposed to Heat-Stress. In A. Daskalaki (Ed.), Handbook of Research on Systems Biology Applications in Medicine (pp. 673-692). IGI Global. https://doi.org/10.4018/978-1-60566-076-9.ch038

Chicago

Dressler, Cathrin, et al. "Fluorescence Imaging of Mitochondrial Long-Term Depolarization in Cancer Cells Exposed to Heat-Stress." In Handbook of Research on Systems Biology Applications in Medicine, edited by Andriani Daskalaki , 673-692. Hershey, PA: IGI Global, 2009. https://doi.org/10.4018/978-1-60566-076-9.ch038

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Abstract

This chapter deals with the mitochondrias’ stress response to heat, which is the central agent of thermotherapy. Thermotherapies function by inducing lethal heat inside target tissues. Spatial and temporal instabilities of temperature distributions in targets require optimized treatment protocols and reliable temperature-control methods during thermotherapies. Since solid cancers present predominant targets to thermotherapy, we analyzed hyperthermic stress-induced effects on mitochondrial transmembrane potentials in breast cancer cells (MX1). Heat sensitivities and stress reactions might be extremely different among different tissue species and tissue dignities; therefore it is very important to investigate tissue-specific stress responses systematically. Even though this chapter provides minimal information only to the enlightenment of systemic cellular heat stress mechanisms, it may contribute to deepening the basic knowledge about systemic stress responses. In addition, the data presented here might support optimizing of treatment protocols applied during thermotherapy, particularly LITT and hyperthermia.

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