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Drug Discovery: Current State and Future Prospects

Drug Discovery: Current State and Future Prospects

S. Lakshmana Prabu
Copyright: © 2019 |Pages: 46
ISBN13: 9781522573265|ISBN10: 1522573267|EISBN13: 9781522573272
DOI: 10.4018/978-1-5225-7326-5.ch001
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MLA

Prabu, S. Lakshmana. "Drug Discovery: Current State and Future Prospects." Computer Applications in Drug Discovery and Development, edited by A. Puratchikody, et al., IGI Global, 2019, pp. 1-46. https://doi.org/10.4018/978-1-5225-7326-5.ch001

APA

Prabu, S. L. (2019). Drug Discovery: Current State and Future Prospects. In A. Puratchikody, S. Prabu, & A. Umamaheswari (Eds.), Computer Applications in Drug Discovery and Development (pp. 1-46). IGI Global. https://doi.org/10.4018/978-1-5225-7326-5.ch001

Chicago

Prabu, S. Lakshmana. "Drug Discovery: Current State and Future Prospects." In Computer Applications in Drug Discovery and Development, edited by A. Puratchikody, S. Lakshmana Prabu, and A. Umamaheswari, 1-46. Hershey, PA: IGI Global, 2019. https://doi.org/10.4018/978-1-5225-7326-5.ch001

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Abstract

Modern chemistry foundations were made in between the 18th and 19th centuries and have been extended in 20th century. R&D towards synthetic chemistry was introduced during the 1960s. Development of new molecular drugs from the herbal plants to synthetic chemistry is the fundamental scientific improvement. About 10-14 years are needed to develop a new molecule with an average cost of more than $800 million. Pharmaceutical industries spend the highest percentage of revenues, but the achievement of desired molecular entities into the market is not increasing proportionately. As a result, an approximate of 0.01% of new molecular entities are approved by the FDA. The highest failure rate is due to inadequate efficacy exhibited in Phase II of the drug discovery and development stage. Innovative technologies such as combinatorial chemistry, DNA sequencing, high-throughput screening, bioinformatics, computational drug design, and computer modeling are now utilized in the drug discovery. These technologies can accelerate the success rates in introducing new molecular entities into the market.

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