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Construction and Analysis of Protein-Protein Interaction Network: Role in Identification of Key Signaling Molecules Involved in a Disease Pathway

Construction and Analysis of Protein-Protein Interaction Network: Role in Identification of Key Signaling Molecules Involved in a Disease Pathway

Divya Dasagrandhi, Arul Salomee Kamalabai Ravindran, Anusuyadevi Muthuswamy, Jayachandran K. S.
Copyright: © 2019 |Pages: 17
ISBN13: 9781522573265|ISBN10: 1522573267|EISBN13: 9781522573272
DOI: 10.4018/978-1-5225-7326-5.ch009
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MLA

Dasagrandhi, Divya, et al. "Construction and Analysis of Protein-Protein Interaction Network: Role in Identification of Key Signaling Molecules Involved in a Disease Pathway." Computer Applications in Drug Discovery and Development, edited by A. Puratchikody, et al., IGI Global, 2019, pp. 204-220. https://doi.org/10.4018/978-1-5225-7326-5.ch009

APA

Dasagrandhi, D., Ravindran, A. S., Muthuswamy, A., & Jayachandran K. S. (2019). Construction and Analysis of Protein-Protein Interaction Network: Role in Identification of Key Signaling Molecules Involved in a Disease Pathway. In A. Puratchikody, S. Prabu, & A. Umamaheswari (Eds.), Computer Applications in Drug Discovery and Development (pp. 204-220). IGI Global. https://doi.org/10.4018/978-1-5225-7326-5.ch009

Chicago

Dasagrandhi, Divya, et al. "Construction and Analysis of Protein-Protein Interaction Network: Role in Identification of Key Signaling Molecules Involved in a Disease Pathway." In Computer Applications in Drug Discovery and Development, edited by A. Puratchikody, S. Lakshmana Prabu, and A. Umamaheswari, 204-220. Hershey, PA: IGI Global, 2019. https://doi.org/10.4018/978-1-5225-7326-5.ch009

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Abstract

Understanding the mechanisms of a disease is highly complicated due to the complex pathways involved in the disease progression. Despite several decades of research, the occurrence and prognosis of the diseases is not completely understood even with high throughput experiments like DNA microarray and next-generation sequencing. This is due to challenges in analysis of huge data sets. Systems biology is one of the major divisions of bioinformatics and has laid cutting edge techniques for the better understanding of these pathways. Construction of protein-protein interaction network (PPIN) guides the modern scientists to identify vital proteins through protein-protein interaction network, which facilitates the identification of new drug target and associated proteins. The chapter is focused on PPI databases, construction of PPINs, and its analysis.

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