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Plasma Cocaine Metabolite Levels and Liver CYP450 3A4 Isoenzyme Activity as Indicators of Cocaine Metabolism in Rats Treated With Salako Supplements

Plasma Cocaine Metabolite Levels and Liver CYP450 3A4 Isoenzyme Activity as Indicators of Cocaine Metabolism in Rats Treated With Salako Supplements

Natwaine Sherune Gardner, Kedon J. S. Luke, Andrew O. Wheatley, Winston De La Haye, Perceval Steven Bahado-Singh, Lowell L. Dilworth, Donovan A. McGrowder, Everard Barton, Lauriann E. Young-Martin, Ajibeke Salako-Akande, Henry Lowe, Errol Morrison, Denise Eldermire-Shearer, Helen Asemota
Copyright: © 2019 |Pages: 21
ISBN13: 9781522554066|ISBN10: 1522554068|ISBN13 Softcover: 9781522586753|EISBN13: 9781522554073
DOI: 10.4018/978-1-5225-5406-6.ch001
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MLA

Gardner, Natwaine Sherune, et al. "Plasma Cocaine Metabolite Levels and Liver CYP450 3A4 Isoenzyme Activity as Indicators of Cocaine Metabolism in Rats Treated With Salako Supplements." Strategic Applications of Measurement Technologies and Instrumentation, edited by Soubantika Palchoudhury, IGI Global, 2019, pp. 1-21. https://doi.org/10.4018/978-1-5225-5406-6.ch001

APA

Gardner, N. S., Luke, K. J., Wheatley, A. O., De La Haye, W., Bahado-Singh, P. S., Dilworth, L. L., McGrowder, D. A., Barton, E., Young-Martin, L. E., Salako-Akande, A., Lowe, H., Morrison, E., Eldermire-Shearer, D., & Asemota, H. (2019). Plasma Cocaine Metabolite Levels and Liver CYP450 3A4 Isoenzyme Activity as Indicators of Cocaine Metabolism in Rats Treated With Salako Supplements. In S. Palchoudhury (Ed.), Strategic Applications of Measurement Technologies and Instrumentation (pp. 1-21). IGI Global. https://doi.org/10.4018/978-1-5225-5406-6.ch001

Chicago

Gardner, Natwaine Sherune, et al. "Plasma Cocaine Metabolite Levels and Liver CYP450 3A4 Isoenzyme Activity as Indicators of Cocaine Metabolism in Rats Treated With Salako Supplements." In Strategic Applications of Measurement Technologies and Instrumentation, edited by Soubantika Palchoudhury, 1-21. Hershey, PA: IGI Global, 2019. https://doi.org/10.4018/978-1-5225-5406-6.ch001

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Abstract

The effects of Salako nutritional supplements on cocaine-dependent Sprague Dawley rats was investigated. Rats were made cocaine-dependent using conditioned place preference (CPP) where craving was analyzed regularly. Cocaine metabolite levels were determined from blood samples. CYP450 3A4 isoenzyme activities were obtained using liver homogenate. Statistical analysis was done using SPSS one-way ANOVA and Duncans multiple range test. Results show that when cocaine use was discontinued, the supplements reduced craving of cocaine significantly. Blood plasma results showed higher benzoylecgonine equilibrium possibly indicating that the supplements aided the removal of stored cocaine metabolites which may have contributed to better management of craving in the rats. CYP450 3A4 isoenzyme activity was further enhanced by the supplements and is indicative of increased cocaine metabolism. The results indicate that the Salako nutritional supplements reduce craving caused by chronic cocaine administration by increasing the liver CYP450 3A4 isoenzyme activity, resulting in better plasma clearance.

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