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Overview of Multicomponent Solid Forms

Overview of Multicomponent Solid Forms

Rahul B. Chavan, Nalini R. Shastri
Copyright: © 2018 |Volume: 3 |Issue: 1 |Pages: 26
ISSN: 2379-7452|EISSN: 2379-7444|EISBN13: 9781522547259|DOI: 10.4018/JNN.2018010102
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MLA

Chavan, Rahul B., and Nalini R. Shastri. "Overview of Multicomponent Solid Forms." JNN vol.3, no.1 2018: pp.23-48. http://doi.org/10.4018/JNN.2018010102

APA

Chavan, R. B. & Shastri, N. R. (2018). Overview of Multicomponent Solid Forms. Journal of Nanotoxicology and Nanomedicine (JNN), 3(1), 23-48. http://doi.org/10.4018/JNN.2018010102

Chicago

Chavan, Rahul B., and Nalini R. Shastri. "Overview of Multicomponent Solid Forms," Journal of Nanotoxicology and Nanomedicine (JNN) 3, no.1: 23-48. http://doi.org/10.4018/JNN.2018010102

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Abstract

Multi-drug therapy involves the simultaneous or sequential administration of two or more drugs with similar or different mechanisms of action and is efficient in combating various ailments such as cancer, diabetes, and rheumatoid arthritis. It has emerged advantageous due to larger therapeutic benefits, an increase in patient compliance, lower administrative costs, and reduced number of prescriptions. In the recent past, the clinical success of the Novartis product Entresto (sacubitril, disodium valsartan and water) and Esteve product E-58425 (tramadol and celecoxib) has boosted the development of multi-drug . The present article is hence designed to provide an overview of different multicomponent addicts which provide option of combining the drugs at a supramolecular level (nano-sized level). Key features of multi-drug cocrystal, co-amorphous system and eutectics are described with major emphasis on screening tools, preparation methods, characterization techniques, biopharmaceutical aspects and scale up.

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