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Protein Structure Prediction

Protein Structure Prediction

Hirak Jyoti Chakraborty, Aditi Gangopadhyay, Sayak Ganguli, Abhijit Datta
Copyright: © 2019 |Pages: 29
ISBN13: 9781522589037|ISBN10: 1522589031|EISBN13: 9781522589044
DOI: 10.4018/978-1-5225-8903-7.ch007
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MLA

Chakraborty, Hirak Jyoti, et al. "Protein Structure Prediction." Biotechnology: Concepts, Methodologies, Tools, and Applications, edited by Information Resources Management Association, IGI Global, 2019, pp. 156-184. https://doi.org/10.4018/978-1-5225-8903-7.ch007

APA

Chakraborty, H. J., Gangopadhyay, A., Ganguli, S., & Datta, A. (2019). Protein Structure Prediction. In I. Management Association (Ed.), Biotechnology: Concepts, Methodologies, Tools, and Applications (pp. 156-184). IGI Global. https://doi.org/10.4018/978-1-5225-8903-7.ch007

Chicago

Chakraborty, Hirak Jyoti, et al. "Protein Structure Prediction." In Biotechnology: Concepts, Methodologies, Tools, and Applications, edited by Information Resources Management Association, 156-184. Hershey, PA: IGI Global, 2019. https://doi.org/10.4018/978-1-5225-8903-7.ch007

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Abstract

The great disagreement between the number of known protein sequences and the number of experimentally determined protein structures indicate an enormous necessity of rapid and accurate protein structure prediction methods. Computational techniques such as comparative modeling, threading and ab initio modelling allow swift protein structure prediction with sufficient accuracy. The three phases of computational protein structure prediction comprise: the pre-modelling analysis phase, model construction and post-modelling refinement. Protein modelling is primarily comparative or ab initio. Comparative or template-based methods such as homology and threading-based modelling require structural templates for constructing the structure of a target sequence. The ab initio is a template-free modelling approach which proceeds by satisfying various physics-based and knowledge-based parameters. The chapter will elaborate on the three phases of modelling, the programs available for performing each, issues, possible solutions and future research areas.

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