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Protein Quality Control in Neurodegeneration and Neuroprotection

Protein Quality Control in Neurodegeneration and Neuroprotection

Yasmeena Akhter, Jahangir Nabi, Hinna Hamid, Nahida Tabassum, Faheem Hyder Pottoo, Aashish Sharma
Copyright: © 2020 |Pages: 24
ISBN13: 9781799813170|ISBN10: 1799813177|EISBN13: 9781799813187
DOI: 10.4018/978-1-7998-1317-0.ch001
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MLA

Akhter, Yasmeena, et al. "Protein Quality Control in Neurodegeneration and Neuroprotection." Quality Control of Cellular Protein in Neurodegenerative Disorders, edited by Md. Sahab Uddin and Ghulam Md. Ashraf, IGI Global, 2020, pp. 1-24. https://doi.org/10.4018/978-1-7998-1317-0.ch001

APA

Akhter, Y., Nabi, J., Hamid, H., Tabassum, N., Pottoo, F. H., & Sharma, A. (2020). Protein Quality Control in Neurodegeneration and Neuroprotection. In M. Uddin & G. Ashraf (Eds.), Quality Control of Cellular Protein in Neurodegenerative Disorders (pp. 1-24). IGI Global. https://doi.org/10.4018/978-1-7998-1317-0.ch001

Chicago

Akhter, Yasmeena, et al. "Protein Quality Control in Neurodegeneration and Neuroprotection." In Quality Control of Cellular Protein in Neurodegenerative Disorders, edited by Md. Sahab Uddin and Ghulam Md. Ashraf, 1-24. Hershey, PA: IGI Global, 2020. https://doi.org/10.4018/978-1-7998-1317-0.ch001

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Abstract

Proteostasis is essential for regulating the integrity of the proteome. Disruption of proteostasis under some rigorous conditions leads to the aggregation and accumulation of misfolded toxic proteins, which plays a central role in the pathogenesis of protein conformational disorders. The protein quality control (PQC) system serves as a multi-level security system to shield cells from abnormal proteins. The intrinsic PQC systems maintaining proteostasis include the ubiquitin-proteasome system (UPS), chaperon-mediated autophagy (CMA), and autophagy-lysosome pathway (ALP) that serve to target misfolded proteins for unfolding, refolding, or degradation. Alterations of PQC systems in neurons have been implicated in the pathogenesis of various neurodegenerative disorders. This chapter provides an overview of PQC pathways to set a framework for discussion of the role of PQC in neurodegenerative disorders. Additionally, various pharmacological approaches targeting PQC are summarized.

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