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Multifarious Role of BAG3 in Neurodegenerative Disorders

Multifarious Role of BAG3 in Neurodegenerative Disorders

Sujata Basu, Manisha Singh, Mansi Verma, Rachana R.
Copyright: © 2020 |Pages: 21
ISBN13: 9781799813170|ISBN10: 1799813177|EISBN13: 9781799813187
DOI: 10.4018/978-1-7998-1317-0.ch010
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MLA

Basu, Sujata, et al. "Multifarious Role of BAG3 in Neurodegenerative Disorders." Quality Control of Cellular Protein in Neurodegenerative Disorders, edited by Md. Sahab Uddin and Ghulam Md. Ashraf, IGI Global, 2020, pp. 261-281. https://doi.org/10.4018/978-1-7998-1317-0.ch010

APA

Basu, S., Singh, M., Verma, M., & R., R. (2020). Multifarious Role of BAG3 in Neurodegenerative Disorders. In M. Uddin & G. Ashraf (Eds.), Quality Control of Cellular Protein in Neurodegenerative Disorders (pp. 261-281). IGI Global. https://doi.org/10.4018/978-1-7998-1317-0.ch010

Chicago

Basu, Sujata, et al. "Multifarious Role of BAG3 in Neurodegenerative Disorders." In Quality Control of Cellular Protein in Neurodegenerative Disorders, edited by Md. Sahab Uddin and Ghulam Md. Ashraf, 261-281. Hershey, PA: IGI Global, 2020. https://doi.org/10.4018/978-1-7998-1317-0.ch010

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Abstract

The glial cells along with cells of hematopoietic origin and microvascular endothelia work together to maintain the normal development and/or functioning of the nervous system. Disruption in functional coordination among these cells interrupts the efficiency of the nervous system, leading to neurodegeneration. Various proteins in the nerve cells maintain the normal signaling mechanism with these cells and throughout the body. Structural/functional disorganization of these proteins causes neurodegenerative disorders. The molecular mechanisms involved in these phenomena are yet to be explored extensively from therapeutic perspectives. Through this chapter, the authors have elaborated on less known protein Bcl-2 associated athanogene 3 (BAG3) involved in neurodegeneration. They have explored BAG3 protein and its role in neurodegeneration, protein homeostasis, its mechanism of action, its uses as a drug target, and its uses as a possible diagnostic marker of neurodegeneration.

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